Here we will summarize the recent advances in CMA biology, highlight ER stress-induced CMA, and discuss the role of CMA in diseases.Ĭancer Chaperone-mediated autophagy ER stress Neurodegenerative disease Parkinson's disease Therapy.Ĭopyright © 2018 Elsevier Inc. As more proteins are identified as CMA substrates, CMA function has been associated with an increasing number of important cellular processes, organelles, and diseases, including neurodegenerative diseases. Although autophagy is considered a nonselective degradation process, CMA is known as a selective degradation pathway. There are three types of autophagy macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). One particularly exciting discovery is how other cellular stress organelles such as ER signal to CMA. Lysosome incorporate and degrade proteins in a process known as autophagy. During the past several years, significant advances have been made in our understanding of how CMA itself is modulated and what physiological and pathological processes it may be involved in. Among the three types of lysosome-based autophagy pathways, chaperone-mediated autophagy (CMA) selectively degrades cellular proteins with KFERQ-like motif by unique machinery. Chaperone-mediated autophagy (CMA) plays an important role in regulating a variety of cellular functions by selectively degrading damaged or functional.

Lysosomes play an important role in degrading and recycling intracellular components via autophagy. It relies on the balance between protein synthesis and degradation. Protein homeostasis or proteostasis is critical for proper cellular function and survival.

Chaperone mediated autophagy 2019